The SYSTERS Protein Family Web Server: Shortcut from large-scale sequence information to phylogenetic information SYSTERS superfamily 114462 comprises most of the Cation efflux domain proteins in Arabidopsis thaliana

With this poster [11], we present the SYSTERS protein family database, an attempt to classify all available protein sequences. In particular, we focus on the capability of the web interface to assist in in-depth analyses of special protein families. We demonstrate this by an analysis of a specific family of transmembraneous metal ion transport proteins characterised by the so called cation efflux domain. We show three strategies to query SYSTERS: 1. by protein domain name as defined in Pfam [1], 2. by a set of sequence database accession numbers, and 3. by SYSTERS superfamily ID. All strategies lead to the identification of relevant SYSTERS protein families with description annotations from the source database entries, links to sequences, annotated alignments, family consensus sequences, phylogenetic trees, phylogenetic profiles, functional annotations, and links to other sequence resources. The analysis presented here documents how SYSTERS can help to generate new hypotheses about the function and evolution of protein families.